RT Journal Article SR Electronic T1 Is True Whole-Body 18F-FDG PET/CT Required in Pediatric Lymphoma? An IAEA Multicenter Prospective Study JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1087 OP 1093 DO 10.2967/jnumed.118.222299 VO 60 IS 8 A1 Cerci, Juliano J. A1 Etchebehere, Elba C. A1 Nadel, Helen A1 Brink, Anita A1 Bal, Chandrasekhar S. A1 Rangarajan, Venkatesh A1 Pfluger, Thomas A1 Kagna, Olga A1 Alonso, Omar A1 Begum, Fatima K. A1 Mir, Kahkashan Bashir A1 Magboo, Vincent P. A1 Menezes, Leon J. A1 Paez, Diana A1 Pascual, Thomas N. YR 2019 UL http://jnm.snmjournals.org/content/60/8/1087.abstract AB Guidelines recommend true whole-body 18F-FDG PET/CT scans from vertex to toes in pediatric lymphoma patients, although this suggestion has not been validated in large clinical trials. The objective of the study was to evaluate the incidence and clinical impact of lesions outside the “eyes to thighs” regular field of view (R-FOV) in 18F-FDG PET/CT staging (sPET) and interim (iPET) scans in pediatric lymphoma patients. Methods: True whole-body sPET and iPET scans were prospectively obtained in pediatric lymphoma patients (11 worldwide centers). Expert panel central review of sPET and iPET scans were evaluated for lymphoma lesions outside the R-FOV and clinical relevance of these findings. Results: A total of 610 scans were obtained in 305 patients. The sPET scans did not show lesions outside the R-FOV in 91.8% of the patients, whereas in 8.2% patients the sPET scans demonstrated lesions also outside the R-FOV (soft tissue, bone, bone marrow, and skin); however, the presence of these lesions did not change the clinical stage of any patient and did not affect treatment decision. Among the 305 iPET scans, there were no new positive 18F-FDG–avid lesions outside the R-FOV, when compared with their paired sPET scans. A single lesion outside the R-FOV on iPET occurred in 1 patient (0.3%), with the primary lesion diagnosed in the femur on sPET that persisted on iPET. Conclusion: The identification of additional lesions outside the R-FOV (eyes to thighs) using 18F-FDG PET/CT has no impact in the definition of the clinical stage of disease and minimal impact in the treatment definition of patients with pediatric lymphoma. As so, R-FOV for both sPET and iPET scans could be performed.