PT - JOURNAL ARTICLE AU - Isabel Schobert AU - Julius Chapiro AU - Nariman Nezami AU - Charlie A. Hamm AU - Bernhard Gebauer AU - MingDe Lin AU - Jeffrey Pollak AU - Lawrence Saperstein AU - Todd Schlachter AU - Lynn J. Savic TI - Quantitative Imaging Biomarkers for <sup>90</sup>Y Distribution on Bremsstrahlung SPECT After Resin-Based Radioembolization AID - 10.2967/jnumed.118.219691 DP - 2019 Aug 01 TA - Journal of Nuclear Medicine PG - 1066--1072 VI - 60 IP - 8 4099 - http://jnm.snmjournals.org/content/60/8/1066.short 4100 - http://jnm.snmjournals.org/content/60/8/1066.full SO - J Nucl Med2019 Aug 01; 60 AB - Our purpose was to identify baseline imaging features in patients with liver cancer that correlate with 90Y distribution on postprocedural SPECT and predict tumor response to transarterial radioembolization (TARE). Methods: This retrospective study was approved by the institutional review board and included 38 patients with hepatocellular carcinoma (HCC) (n = 23; 18/23 men; mean age, 62.39 ± 8.62 y; 34 dominant tumors) and non-HCC hepatic malignancies (n = 15; 9/15 men; mean age, 61.13 ± 11.51 y; 24 dominant tumors) who underwent 40 resin-based TARE treatments (August 2012 to January 2018). Multiphasic contrast-enhanced MRI or CT was obtained before and Bremsstrahlung SPECT within 2 h after TARE. Total tumor volume (cm3) and enhancing tumor volume (ETV [cm3] and % of total tumor volume), and total and enhancing tumor burden (%), were volumetrically assessed on baseline imaging. Up to 2 dominant tumors per treated lobe were analyzed. After multimodal image registration of baseline imaging and SPECT/CT, 90Y distribution was quantified on SPECT as tumor–to–normal-liver ratio (TNR). Response was assessed according to RECIST1.1 and quantitative European Association for the Study of the Liver criteria. Clinical parameters were also assessed. Statistical tests included Mann–Whitney U, Pearson correlation, and linear regression. Results: In HCC patients, high baseline ETV% significantly correlated with high TNR on SPECT, demonstrating greater 90Y uptake in the tumor relative to the liver parenchyma (P &lt; 0.001). In non-HCC patients, a correlation between ETV% and TNR was observed as well (P = 0.039). Follow-up imaging for response assessments within 1–4 mo after TARE was available for 23 patients with 25 treatments. The change of ETV% significantly correlated with TNR in HCC (P = 0.039) but not in non-HCC patients (P = 0.886). Additionally, Child–Pugh class B patients demonstrated significantly more 90Y deposition in nontumorous liver than Child–Pugh A patients (P = 0.021). Conclusion: This study identified ETV% as a quantifiable imaging biomarker on preprocedural MRI and CT to predict 90Y distribution on postprocedural SPECT in HCC and non-HCC. However, the relationship between the preferential uptake of 90Y to the tumor and tumor response after radioembolization could be validated only for HCC.