TY - JOUR T1 - Development of Dedicated Brain PET Imaging Devices: Recent Advances and Future Perspectives JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1044 LP - 1052 DO - 10.2967/jnumed.118.217901 VL - 60 IS - 8 AU - Ciprian Catana Y1 - 2019/08/01 UR - http://jnm.snmjournals.org/content/60/8/1044.abstract N2 - Whole-body PET scanners are not optimized for imaging small structures in the human brain. Several PET devices specifically designed for this task have been proposed either for stand-alone operation or as MR-compatible inserts. The main distinctive features of some of the most recent concepts and their performance characteristics, with a focus on spatial resolution and sensitivity, are reviewed. The trade-offs between the various performance characteristics, desired capabilities, and cost that need to be considered when designing a dedicated brain scanner are presented. Finally, the aspirational goals for future-generation scanners, some of the factors that have contributed to the current status, and how recent advances may affect future developments in dedicated brain PET instrumentation are briefly discussed. ER -