PT  - JOURNAL ARTICLE
AU  - Catana, Ciprian
TI  - Development of Dedicated Brain PET Imaging Devices: Recent Advances and Future Perspectives
AID  - 10.2967/jnumed.118.217901
DP  - 2019 Aug 01
TA  - Journal of Nuclear Medicine
PG  - 1044--1052
VI  - 60
IP  - 8
4099  - http://jnm.snmjournals.org/content/60/8/1044.short
4100  - http://jnm.snmjournals.org/content/60/8/1044.full
SO  - J Nucl Med2019 Aug 01; 60
AB  - Whole-body PET scanners are not optimized for imaging small structures in the human brain. Several PET devices specifically designed for this task have been proposed either for stand-alone operation or as MR-compatible inserts. The main distinctive features of some of the most recent concepts and their performance characteristics, with a focus on spatial resolution and sensitivity, are reviewed. The trade-offs between the various performance characteristics, desired capabilities, and cost that need to be considered when designing a dedicated brain scanner are presented. Finally, the aspirational goals for future-generation scanners, some of the factors that have contributed to the current status, and how recent advances may affect future developments in dedicated brain PET instrumentation are briefly discussed.