TY - JOUR T1 - Recent Advances in Imaging Steroid Hormone Receptors in Breast Cancer JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 172 LP - 176 DO - 10.2967/jnumed.119.228858 VL - 61 IS - 2 AU - Manoj Kumar AU - Kelley Salem AU - Amye J. Tevaarwerk AU - Roberta M. Strigel AU - Amy M. Fowler Y1 - 2020/02/01 UR - http://jnm.snmjournals.org/content/61/2/172.abstract N2 - Estrogen receptor (ER) and progesterone receptor (PR) are important prognostic and predictive biomarkers in breast cancer. PET using ER- and PR-specific radioligands enables a whole-body, noninvasive assessment of receptor expression. Recent investigations of ER imaging with 18F-fluoroestradiol have focused on diagnosing ER-positive metastatic disease, optimizing ER-targeted drug dosage, and predicting endocrine therapy benefit. Studies of PR imaging with 18F-fluorofuranyl norprogesterone have investigated how imaging changes in PR expression as a downstream target of ER activation may reflect an early response to ER-targeted therapy. This focused review highlights recent achievements in preclinical and clinical imaging of ER and PR in breast cancer. ER -