RT Journal Article
SR Electronic
T1 Recent Advances in Imaging Steroid Hormone Receptors in Breast Cancer
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 172
OP 176
DO 10.2967/jnumed.119.228858
VO 61
IS 2
A1 Kumar, Manoj
A1 Salem, Kelley
A1 Tevaarwerk, Amye J.
A1 Strigel, Roberta M.
A1 Fowler, Amy M.
YR 2020
UL http://jnm.snmjournals.org/content/61/2/172.abstract
AB Estrogen receptor (ER) and progesterone receptor (PR) are important prognostic and predictive biomarkers in breast cancer. PET using ER- and PR-specific radioligands enables a whole-body, noninvasive assessment of receptor expression. Recent investigations of ER imaging with 18F-fluoroestradiol have focused on diagnosing ER-positive metastatic disease, optimizing ER-targeted drug dosage, and predicting endocrine therapy benefit. Studies of PR imaging with 18F-fluorofuranyl norprogesterone have investigated how imaging changes in PR expression as a downstream target of ER activation may reflect an early response to ER-targeted therapy. This focused review highlights recent achievements in preclinical and clinical imaging of ER and PR in breast cancer.