PT  - JOURNAL ARTICLE
AU  - Enrico Fantoni
AU  - Lyduine Collij
AU  - Isadora Lopes Alves
AU  - Christopher Buckley
AU  - Gill Farrar
TI  - The Spatial-Temporal Ordering of Amyloid Pathology and Opportunities for PET Imaging
AID  - 10.2967/jnumed.119.235879
DP  - 2020 Feb 01
TA  - Journal of Nuclear Medicine
PG  - 166--171
VI  - 61
IP  - 2
4099  - http://jnm.snmjournals.org/content/61/2/166.short
4100  - http://jnm.snmjournals.org/content/61/2/166.full
SO  - J Nucl Med2020 Feb 01; 61
AB  - Although clinical routine focuses on dichotomous and visual interpretation of amyloid PET, regional image assessment in research settings may yield additional opportunities. Understanding the regional-temporal evolution of amyloid pathology may enable earlier identification of subjects in the Alzheimer Disease pathologic continuum, as well as a finer-grained assessment of pathology beyond traditional dichotomous measures. This review summarizes current research in the detection of regional amyloid deposition patterns and its potential for staging amyloid pathology. Pathology studies, cross-sectional and longitudinal PET-only studies, and comparative PET and autopsy studies are included. Despite certain differences, cortical deposition generally precedes striatal pathology, and in PET-only studies, medial cortical regions are seen to accumulate amyloid earlier than lateral regions. Based on regional amyloid PET, multiple studies have developed and implemented models for staging amyloid pathology that could improve subject selection into secondary prevention trials and visual assessment in clinical routine.