PT  - JOURNAL ARTICLE
AU  - Rowe, Steven P.
AU  - Campbell, Scott P.
AU  - Mana-Ay, Margarita
AU  - Szabo, Zsolt
AU  - Allaf, Mohamad E.
AU  - Pienta, Kenneth J.
AU  - Pomper, Martin G.
AU  - Ross, Ashley E.
AU  - Gorin, Michael A.
TI  - Prospective Evaluation of PSMA-Targeted <sup>18</sup>F-DCFPyL PET/CT in Men with Biochemical Failure After Radical Prostatectomy for Prostate Cancer
AID  - 10.2967/jnumed.119.226514
DP  - 2020 Jan 01
TA  - Journal of Nuclear Medicine
PG  - 58--61
VI  - 61
IP  - 1
4099  - http://jnm.snmjournals.org/content/61/1/58.short
4100  - http://jnm.snmjournals.org/content/61/1/58.full
SO  - J Nucl Med2020 Jan 01; 61
AB  - Our purpose is to provide the results of a prospective study evaluating prostate-specific membrane antigen–targeted 18F-DCFPyL (2-(3-{1-carboxy-5-[(6-18F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid) PET/CT in patients with biochemical failure after radical prostatectomy for prostate cancer (PCa). Methods: Thirty-one patients with postprostatectomy serum prostate-specific antigen (PSA) levels of at least 0.2 ng/mL and negative conventional imaging results were enrolled in this study and imaged with 18F-DCFPyL PET/CT. A consensus central review identified foci of radiotracer uptake consistent with sites of PCa. Descriptive statistics were used. Results: Twenty-one patients (67.7%) had at least 1 finding on 18F-DCFPyL PET/CT consistent with a site of PCa. Imaging was positive in 59.1% of patients with a PSA level of less than 1.0 ng/mL and in 88.9% of patients with a PSA level of more than 1.0 ng/mL. The median SUVmax across all lesions was 11.6 (range, 1.5–57.6). Conclusion: In this prospective study using the prostate-specific membrane antigen–targeted PET agent 18F-DCFPyL, most patients with biochemical failure after radical prostatectomy had foci of suggestive uptake, even at low serum PSA levels.