TY - JOUR T1 - Trending: Radioactive and Fluorescent Bimodal/Hybrid Tracers as Multiplexing Solutions for Surgical Guidance JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 13 LP - 19 DO - 10.2967/jnumed.119.228684 VL - 61 IS - 1 AU - Fijs W.B. van Leeuwen AU - Margret Schottelius AU - Oscar R. Brouwer AU - Sergi Vidal-Sicart AU - Samuel Achilefu AU - Joachim Klode AU - Hans-Jurgen Wester AU - Tessa Buckle Y1 - 2020/01/01 UR - http://jnm.snmjournals.org/content/61/1/13.abstract N2 - By contributing to noninvasive molecular imaging and radioguided surgery, nuclear medicine has been instrumental in the realization of precision medicine. During the last decade, it has also become apparent that nuclear medicine (e.g., in the form of bimodal/hybrid tracers) can help to empower fluorescence-guided surgery. More specifically, when using hybrid tracers, lesions can be noninvasively identified and localized with a high sensitivity and precision (guided by the radioisotope) and ultimately resected under real-time optical guidance (fluorescent dye). This topical review discusses early clinical successes, preclinical directions, and key aspects that could have an impact on the future of this field. ER -