RT Journal Article
SR Electronic
T1 Trending: Radioactive and Fluorescent Bimodal/Hybrid Tracers as Multiplexing Solutions for Surgical Guidance
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 13
OP 19
DO 10.2967/jnumed.119.228684
VO 61
IS 1
A1 van Leeuwen, Fijs W.B.
A1 Schottelius, Margret
A1 Brouwer, Oscar R.
A1 Vidal-Sicart, Sergi
A1 Achilefu, Samuel
A1 Klode, Joachim
A1 Wester, Hans-Jurgen
A1 Buckle, Tessa
YR 2020
UL http://jnm.snmjournals.org/content/61/1/13.abstract
AB By contributing to noninvasive molecular imaging and radioguided surgery, nuclear medicine has been instrumental in the realization of precision medicine. During the last decade, it has also become apparent that nuclear medicine (e.g., in the form of bimodal/hybrid tracers) can help to empower fluorescence-guided surgery. More specifically, when using hybrid tracers, lesions can be noninvasively identified and localized with a high sensitivity and precision (guided by the radioisotope) and ultimately resected under real-time optical guidance (fluorescent dye). This topical review discusses early clinical successes, preclinical directions, and key aspects that could have an impact on the future of this field.