PT  - JOURNAL ARTICLE
AU  - van Leeuwen, Fijs W.B.
AU  - Schottelius, Margret
AU  - Brouwer, Oscar R.
AU  - Vidal-Sicart, Sergi
AU  - Achilefu, Samuel
AU  - Klode, Joachim
AU  - Wester, Hans-Jurgen
AU  - Buckle, Tessa
TI  - Trending: Radioactive and Fluorescent Bimodal/Hybrid Tracers as Multiplexing Solutions for Surgical Guidance
AID  - 10.2967/jnumed.119.228684
DP  - 2020 Jan 01
TA  - Journal of Nuclear Medicine
PG  - 13--19
VI  - 61
IP  - 1
4099  - http://jnm.snmjournals.org/content/61/1/13.short
4100  - http://jnm.snmjournals.org/content/61/1/13.full
SO  - J Nucl Med2020 Jan 01; 61
AB  - By contributing to noninvasive molecular imaging and radioguided surgery, nuclear medicine has been instrumental in the realization of precision medicine. During the last decade, it has also become apparent that nuclear medicine (e.g., in the form of bimodal/hybrid tracers) can help to empower fluorescence-guided surgery. More specifically, when using hybrid tracers, lesions can be noninvasively identified and localized with a high sensitivity and precision (guided by the radioisotope) and ultimately resected under real-time optical guidance (fluorescent dye). This topical review discusses early clinical successes, preclinical directions, and key aspects that could have an impact on the future of this field.