@article {Perkins1691, author = {Lydia A. Perkins and Carolyn J. Anderson and Enrico M. Novelli}, title = {Targeting P-Selectin Adhesion Molecule in Molecular Imaging: P-Selectin Expression as a Valuable Imaging Biomarker of Inflammation in Cardiovascular Disease}, volume = {60}, number = {12}, pages = {1691--1697}, year = {2019}, doi = {10.2967/jnumed.118.225169}, publisher = {Society of Nuclear Medicine}, abstract = {P-selectin is an adhesion molecule translocated to the surface of endothelial cells and platelets under inflammatory stimuli, and its potential as a biomarker in inflammatory conditions has driven preclinical studies to investigate its application for molecular imaging of inflammation. Clinical imaging of P-selectin expression for disease characterization could have an important role in stratifying patients and determining treatment strategies. The objective of this review is to outline the role of P-selectin in cardiovascular inflammatory conditions and its translation as an early inflammatory biomarker for several molecular imaging modalities for diagnostic purposes and therapeutic planning.}, issn = {0161-5505}, URL = {https://jnm.snmjournals.org/content/60/12/1691}, eprint = {https://jnm.snmjournals.org/content/60/12/1691.full.pdf}, journal = {Journal of Nuclear Medicine} }