RT Journal Article
SR Electronic
T1 A Fully Automatic Technique for Precise Localization and Quantification of Amyloid-β PET Scans
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1771
OP 1779
DO 10.2967/jnumed.119.228510
VO 60
IS 12
A1 Tahmi, Mouna
A1 Bou-Zeid, Wassim
A1 Razlighi, Qolamreza R.
YR 2019
UL http://jnm.snmjournals.org/content/60/12/1771.abstract
AB Spatial heterogeneity in the accumulation of amyloid-β plaques throughout the brain during asymptomatic as well as clinical stages of Alzheimer disease calls for precise localization and quantification of this protein using PET imaging. To address this need, we have developed and evaluated a technique that quantifies the extent of amyloid-β pathology on a millimeter-by-millimeter scale in the brain with unprecedented precision using data from PET scans. Methods: An intermodal and intrasubject registration with normalized mutual information as the cost function was used to transform all FreeSurfer neuroanatomic labels into PET image space, which were subsequently used to compute regional SUV ratio (SUVR). We have evaluated our technique using postmortem histopathologic staining data from 52 older participants as the standard-of-truth measurement. Results: Our method resulted in consistently and significantly higher SUVRs in comparison to the conventional method in almost all regions of interest. A 2-way ANOVA revealed a significant main effect of method as well as a significant interaction effect of method on the relationship between computed SUVR and histopathologic staining score. Conclusion: These findings suggest that processing the amyloid-β PET data in subjects’ native space can improve the accuracy of the computed SUVRs, as they are more closely associated with the histopathologic staining data than are the results of the conventional approach.