PT - JOURNAL ARTICLE AU - Helle D. Zacho AU - Mads R. Jochumsen AU - Niels C. Langkilde AU - Jesper C. Mortensen AU - Christian Haarmark AU - Helle W. Hendel AU - Jørgen B. Jensen AU - Lars J. Petersen TI - No Added Value of <sup>18</sup>F-Sodium Fluoride PET/CT for the Detection of Bone Metastases in Patients with Newly Diagnosed Prostate Cancer with Normal Bone Scintigraphy AID - 10.2967/jnumed.119.229062 DP - 2019 Dec 01 TA - Journal of Nuclear Medicine PG - 1713--1716 VI - 60 IP - 12 4099 - http://jnm.snmjournals.org/content/60/12/1713.short 4100 - http://jnm.snmjournals.org/content/60/12/1713.full SO - J Nucl Med2019 Dec 01; 60 AB - The aim of this study was to determine if additional 18F-sodium fluoride PET/CT (NaF PET/CT) improves the prognostic accuracy in the initial staging of prostate cancer patients with normal bone scintigraphy undergoing prostatectomy. Methods: A prospective cohort study examined NaF PET/CT in intermediate- or high-risk prostate cancer with negative bone scintigraphy who were scheduled for prostatectomy. Biochemical response: PSA levels &lt; 0.2 ng/mL at 6 wk and 6 mo postoperatively, PSA level ≥ 0.2 ng/mL was biochemical failure. Results: Eighty-one patients were included in the study; 75 patients (93%) achieved biochemical responses, 6 patients had biochemical failure. NaF PET/CT indicated bone metastasis in 1 patient (1.2%), was equivocal in 7 patients (8.6%), without bone metastases in 73 patients (90.1%). Eight patients with bone metastases or equivocal results on NaF PET/CT exhibited biochemical responses. All patients with biochemical failure had negative NaF PET/CT and bone scintigraphy for bone metastases. Conclusion: NaF PET/CT has no added value for bone staging in intermediate- and high-risk prostate cancer patients with normal bone scintigraphy results undergoing prostatectomy.