PT  - JOURNAL ARTICLE
AU  - Kambiz Rahbar
AU  - Lisa Bodei
AU  - Michael J. Morris
TI  - Is the Vision of Radioligand Therapy for Prostate Cancer Becoming a Reality? An Overview of the Phase III VISION Trial and Its Importance for the Future of Theranostics
AID  - 10.2967/jnumed.119.234054
DP  - 2019 Nov 01
TA  - Journal of Nuclear Medicine
PG  - 1504--1506
VI  - 60
IP  - 11
4099  - http://jnm.snmjournals.org/content/60/11/1504.short
4100  - http://jnm.snmjournals.org/content/60/11/1504.full
SO  - J Nucl Med2019 Nov 01; 60
AB  - Prostate-specific membrane antigen (PSMA) is of considerable interest as a target for diagnostics and therapy of prostate cancer patients. PSMA-targeted imaging has demonstrable value in guiding the management of the clinical evolution of prostatic cancer. The use of PSMA-targeted therapy using 177Lu-labeled PSMA-617 is similarly effective and is progressing toward approval. The phase III VISION trial represents the largest well-designed and executed study of a theranostic pair. This article provides an overview of the phase III trial and delineates the different study arms and their implications in the assessment of efficacy. The VISION (phase III) trial will provide data of critical value to the field of theranostics and especially the field of prostatic cancer management.