TY - JOUR T1 - A Prospective Study on <sup>18</sup>F-DCFPyL PSMA PET/CT Imaging in Biochemical Recurrence of Prostate Cancer JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1587 LP - 1593 DO - 10.2967/jnumed.119.226381 VL - 60 IS - 11 AU - Etienne Rousseau AU - Don Wilson AU - Frédéric Lacroix-Poisson AU - Andra Krauze AU - Kim Chi AU - Martin Gleave AU - Michael McKenzie AU - Scott Tyldesley AU - S. Larry Goldenberg AU - François Bénard Y1 - 2019/11/01 UR - http://jnm.snmjournals.org/content/60/11/1587.abstract N2 - 18F-DCFPyL (2-(3-{1-carboxy-5-[(6-18F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid), a prostate-specific membrane antigen–targeting radiotracer, has shown promise as a prostate cancer imaging radiotracer. We evaluated the safety, sensitivity, and impact on patient management of 18F-DCFPyL in the setting of biochemical recurrence of prostate cancer. Methods: Subjects with prostate cancer and biochemical recurrence after radical prostatectomy or curative-intent radiotherapy were included in this prospective study. The subjects underwent 18F-DCFPyL PET/CT imaging. The localization and number of lesions were recorded. The uptake characteristics of the 5 most active lesions were measured. A pre- and posttest questionnaire was sent to treating physicians to assess the impact on management. Results: One hundred thirty subjects were evaluated. 18F-DCFPyL PET/CT localized recurrent prostate cancer in 60% of cases with a prostate-specific antigen (PSA) level of ≥0.4 to &lt;0.5, 78% with a level of ≥0.5 to &lt;1.0, 72% with a level of ≥1.0 to &lt;2.0, and 92% with a level of ≥2.0. Many subjects had few lesions (1 lesion in 40.8%, 2 in 8.5%, and 3 in 4.6%). The number of lesions was significantly related to PSA by ANOVA, but there was a large overlap in the PSA values for number of lesion categories. Total lesion uptake was also significantly related to PSA level. A change in treatment intent occurred in 65.5% of subjects, disease stage changed in 65.5%, and management plans changed in 87.3%. Twenty-two subjects reported mild adverse events after the scan; all resolved completely. Conclusion: 18F-DCFPyL PET/CT is safe and sensitive for the localization of biochemical recurrence of prostate cancer. This test improved decision making for referring oncologists and changed management for most subjects. ER -