PT - JOURNAL ARTICLE AU - Ernest V. Garcia AU - Piotr Slomka AU - Jonathan B. Moody AU - Guido Germano AU - Edward P. Ficaro TI - Quantitative Clinical Nuclear Cardiology, Part 1: Established Applications AID - 10.2967/jnumed.119.229799 DP - 2019 Nov 01 TA - Journal of Nuclear Medicine PG - 1507--1516 VI - 60 IP - 11 4099 - http://jnm.snmjournals.org/content/60/11/1507.short 4100 - http://jnm.snmjournals.org/content/60/11/1507.full SO - J Nucl Med2019 Nov 01; 60 AB - SPECT myocardial perfusion imaging has attained widespread clinical acceptance as a standard of care for patients with known or suspected coronary artery disease. A significant contribution to this success has been the use of computer techniques to provide objective quantitative assessment in the standardization of the interpretation of these studies. Software platforms have been developed as a pipeline to provide the quantitative algorithms researched, developed and validated to be clinically useful so diagnosticians everywhere can benefit from these tools. The goal of this continuing medical education article (part 1) is to describe the many quantitative tools that are clinically established and, more importantly, how clinicians should use them routinely in interpretation, clinical management, and therapy guidance for patients with coronary artery disease.