PT  - JOURNAL ARTICLE
AU  - Roll, Wolfgang
AU  - Markwardt, Niklas A.
AU  - Masthoff, Max
AU  - Helfen, Anne
AU  - Claussen, Jing
AU  - Eisenblätter, Michel
AU  - Hasenbach, Alexa
AU  - Hermann, Sven
AU  - Karlas, Angelos
AU  - Wildgruber, Moritz
AU  - Ntziachristos, Vasilis
AU  - Schäfers, Michael
TI  - Multispectral Optoacoustic Tomography of Benign and Malignant Thyroid Disorders: A Pilot Study
AID  - 10.2967/jnumed.118.222174
DP  - 2019 Oct 01
TA  - Journal of Nuclear Medicine
PG  - 1461--1466
VI  - 60
IP  - 10
4099  - http://jnm.snmjournals.org/content/60/10/1461.short
4100  - http://jnm.snmjournals.org/content/60/10/1461.full
SO  - J Nucl Med2019 Oct 01; 60
AB  - This study aimed at evaluating hybrid multispectral optoacoustic tomography/ultrasound for imaging of thyroid disorders, including Graves’ disease and thyroid nodules. Methods: The functional biomarkers and tissue parameters deoxygenated hemoglobin, oxygenated hemoglobin, total hemoglobin, saturation of hemoglobin, fat content, and water content were analyzed in thyroid lobes affected by Graves’ disease (n = 6), thyroid lobes with healthy tissue (n = 8), benign thyroid nodules (n = 13), and malignant thyroid nodules (n = 3). Results: In Graves’ disease, significantly higher deoxygenated hemoglobin (3.18 ± 0.52 vs. 2.13 ± 0.62; P = 0.0055) and total hemoglobin (8.34 ± 0.88 vs. 6.59 ± 1.16; P = 0.0084) and significantly lower fat content (0.64 ± 0.37 vs. 1.69 ± 1.25; P = 0.0293) were found than in healthy controls. Malignant thyroid nodules showed significantly lower saturation of hemoglobin (55.4% ± 2.6% vs. 60.8% ± 7.2%; P = 0.0393) and lower fat content (0.62 ± 0.19 vs. 1.46 ± 0.87; P = 0.1295) than benign nodules. Conclusion: This pilot study showed the applicability and the potential of hybrid multispectral optoacoustic tomography/ultrasound to semiquantitatively provide tissue characterization and functional parameters in thyroid disorders for improved noninvasive diagnostics of thyroid diseases.