TY - JOUR T1 - <sup>99m</sup>Tc-TRODAT-1 SPECT imaging findings and clinical staging of Parkinson ’s disease: Does a correlation exist? JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 425 LP - 425 VL - 60 IS - supplement 1 AU - Vanshika Gupta AU - Ritu Verma AU - Rajeev Ranjan AU - Ethel Belho AU - Harsh Mahajan Y1 - 2019/05/01 UR - http://jnm.snmjournals.org/content/60/supplement_1/425.abstract N2 - 425Objectives: To assess the pattern of 99mTc-TRODAT-1 binding and to establish correlation between decline in 99mTc-TRODAT-1 uptake with increasing disease severity of Parkinson’s disease as given clinically by Modified Hoehn and Yahr stage. Methods: 241 patients diagnosed as clinically probable PD who underwent 99mTc-TRODAT-1 SPECT scan were included. Binding ratios (BR) were calculated for each basal ganglia by drawing region of interest (RoI). Occipital RoI was taken for background correction. Correlation of BR with increasing clinical stage as given by Modified Hoehn and Yahr (HY) scale was derived. Patients were clinically categorized into postural-instability gait disorders (PIGD) group and tremor-dominant PD (TD) group. Results: A statistically significant negative correlation was found between increasing disease severity as given by HY and BR in all sub-regions of the striatum. A significant decline was noted in the binding ratio of the putamen as compared to caudate in all sub-groups. No significant asymmetry was found between the left and right striatum in patients belonging to PIGD group and in those with bilateral tremors without lateralization. Conclusion: Significant asymmetry with the contralateral side being affected more than the ipsilateral side was a hallmark in patients with lateralization of symptoms, i.e. in TD PD group. The binding ratio of the ipsilateral striatum may serve useful in following the progression of the disease and in prognosticating the clinical course, as it represents the level of remaining functional dopaminergic neuronal reserve in the striatum. ER -