PT - JOURNAL ARTICLE AU - Laetitia Imbert AU - Julien Jurczak AU - Mathieu PERRIN AU - Gilles Karcher AU - Pierre-Yves Marie AU - Antoine Verger TI - Image quality of brain SPECT recorded with the whole-body Veriton CZT camera and a focal brain configuration of detectors, as compared with conventional SPECT and PET systems DP - 2019 May 01 TA - Journal of Nuclear Medicine PG - 1395--1395 VI - 60 IP - supplement 1 4099 - http://jnm.snmjournals.org/content/60/supplement_1/1395.short 4100 - http://jnm.snmjournals.org/content/60/supplement_1/1395.full SO - J Nucl Med2019 May 01; 60 AB - 1395Introduction: The whole-body "Veriton” CZT-camera (Spectrum Dynamics Medical®) is equipped with 12 swivelling high-resolution detectors regularly spaced over 360 degrees and covering an axial field-of view of 32 cm. These detectors may be placed close to the head and to any other part of the body, providing a high-count sensitivity. This study was aimed to assess the quality of the perfusion brain images provided by this CZT-SPECT system, as compared with conventional Anger-SPECT and additionally, with the 18F-FDG brain images from analog and digital PET systems. Methods: Image quality parameters of brain 99mTc-HMPAO images from a Hoffman phantom and from normal patients were compared between the Veriton camera and a conventional Anger camera equipped with parallel-hole collimators (Symbia T2, Siemens Healthineers®) and with further comparisons of 18F-FDG brain images from analog (Biograph6 True Point, Siemens Healthineers®) and digital (Vereos, Philips Medical Systems®) PET cameras, all performed with routine parameters. Images were reconstructed with a similar level of convergence for each iterative reconstruction process, corrections for attenuation and diffusion, current resolution recovery systems with the recommended voxel sizes, ranging from 2 to 3.9 mm. Results: When compared with conventional-SPECT, CZT-SPECT exhibited marked enhancements in tomographic count sensitivity (phantom: +260%), in the spatial resolution assessed on the grey-matter cortex with a sharpness index (phantom: +53% and patients: +44%) and in the cortical grey-matter / white-matter contrast (+33% and +55%). These enhancements were still documented with half-time CZT-SPECT acquisitions (+49 and +41% for spatial resolution, +36% and +52% for contrast). These image quality parameters were nevertheless lower than those observed with 18F-FDG PET, although the difference was relatively limited with analog-PET (-3% and -7% for spatial resolution, -2% and -16% for contrast) and more marked with digital-PET (-8% and -14% for spatial resolution; -6% and -41% for contrast). Conclusions: The quality of the brain perfusion images recorded with the high-sensitivity Veriton CZT-camera is dramatically higher than that provided by a conventional Anger camera and rather close to that observed for the 18F-FDG brain images from an analog PET, thereby providing a potential alternative to 18F-FDG PET for functional brain imaging.