PT  - JOURNAL ARTICLE
AU  - Novruzov, Fuad
AU  - Aliyev, Jamil
AU  - Rehimzade, Sevinc
AU  - Mahmudlu, Sara
AU  - Jumazade, Elmira
AU  - Mansurov, Elcin
AU  - Melikova, Leylakhanim
AU  - Talibova, Narmin
AU  - Abasov, Bahadur
AU  - Mehmetbeyli, Leyla
AU  - Mehdi, Elnur
TI  - Correlation between 18F-FDG PET/CT standardized uptake value with prognostic factors and gene expression profiles in breast cancer: Single center study from Azerbaijan
DP  - 2019 May 01
TA  - Journal of Nuclear Medicine
PG  - 1234--1234
VI  - 60
IP  - supplement 1
4099  - http://jnm.snmjournals.org/content/60/supplement_1/1234.short
4100  - http://jnm.snmjournals.org/content/60/supplement_1/1234.full
SO  - J Nucl Med2019 May 01; 60
AB  - 1234Objectives: The main purpose of this study is to identify relation between SUVmax value of breast lesions and prognostic factors especially aggressiveness factor Ki-67 index, gene expression profiles of ERCC1, TYMS, RRM1, TUBB3 genes, breast cancer molecular subtypes in breast cancer. Material and Methods: Study subjects were 430 breast cancer patients at initial presentation who underwent 18F-FDG PET/CT. Relations between SUVmax value of breast lesions and age of patient, SUVmax value axillary lymph node lesions, receptor status, Ki-67 index, gene expression profiles of ERCC1, TYMS, RRM1, TUBB3 genes, lymph node metastasis and any distant metastasis were analyzed expression was assessed by one-way ANOVA, Chi-squared test and Spearman correlation test. There were 97 cases with Ki-67 index results among 430 breast cancer patients. Results: In analysis, SUVmax value of breast lesions were associated with age, SUVmax value of axillary lymph node lesion, Ki-67 level, LN metastasis and distant solid organ metastasis. There were positive correlation between SUVmax value of breast lesions and SUVmax value of axillary lymph nodes, Ki-67 level, distant solid organ metastasis (r=0.463, p<0.0001, n=112; r=0,285, p=0.0046, n=97; r=0.365, p<0.0001, n=192, respectively) and negative correlation between SUVmax value of breast lesions and patient age (r= -0,148 and p=0,0409, n=192). There were no any significant relations between PET-CT SUVmax value of breast lesions and breast cancer molecular subtypes (Luminal A, B, HER2-enriched, triple-negative) and gene expression profiles of ERCC1, TYMS, RRM1, TUBB3 genes. Conclusions: Studies have found that tumors with higher levels of Ki-67 have a poor prognosis relation to tumors with lower levels. The positive correlation was found between SUVmax value and Ki-67 help to identify tumors with more aggressive behaviour. Acknowledgement: This study supported by funding from the Science Development Foundation under the President of the Republic of Azerbaijan [Grant № EİF-2014-9(24)-KETPL-14/13/3]