TY - JOUR T1 - The role of <sup>18</sup>F-FDG PET/CT in the evaluation of pericardial effusion JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1275 LP - 1275 VL - 60 IS - supplement 1 AU - Dan Shao AU - shuxia wang Y1 - 2019/05/01 UR - http://jnm.snmjournals.org/content/60/supplement_1/1275.abstract N2 - 1275Objectives: To assess the value of integrated 18F-fluorodeoxyglucose (FDG) PET/CT in differentiation of malignant and benign pericardial effusion. Methods: 18F-FDG PET/CT were performed in 41 patients with pericardial effusion.The detected soft tissue tumor or nodulous lession in pericardium or the thickened pericardium,with the maximum standardized uptake value(SUVmax)≥2.5, was defined as PET/CT-positive.The invaded lession in pericardium with SUV≥2.5 was also as the positive.The difference of SUVmax of benign and malignant lesions was analyzed with two-independent-sample test of nonparametric tests. The final diagnosis was confirmed by biopsy or post-operative pathology. Results: The diagnosis were confirmed with 25 malignant and 16 benign lesions. The median of SUVmax was 6.3 in malignancy group and 2.4 in benign group (z=-3.278,P=0.001). According to the pathology results, there were one false negative case and two false positive cases with PET/CT imaging interpretation. The sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) of 18F-FDG PET/CT in diagnosis of benignity or malignance of pericardium effusion were 96.0%(24/25), 87.5%(14/16),92.7%(38/41), 92.3%(24/26) and 87.5%(14/16), respectively. Conclusions: For the patients with pericardium effusion 18F-FDG PET/CT may be a helpful modality for malignancy differentiation. ER -