RT Journal Article
SR Electronic
T1 PET-CT tumor imaging with <sup>64</sup>CuCl<sub>2</sub>: Early experience with brain tumor imaging
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1502
OP 1502
VO 60
IS supplement 1
A1 Gambhir, Sanjay
A1 Kumar, Vipin
A1 Ora, Manish
A1 Kheruka, Subhash
A1 Dixit, Manish
A1 Kanti Das, Kuntal
A1 Mehrotra, Anant
YR 2019
UL http://jnm.snmjournals.org/content/60/supplement_1/1502.abstract
AB 1502Background: Copper transporter receptor (CTR) have been postulated to be present only in high grade brain tumors/ Glioma. This knowledge obtained from imaging with Copper will further help to choose potential candidate for theragnostic therapy with other copper isotopes. We report preliminary evidence of 64CuCl2 uptake in various grades of brain tumors to aim towards this goal. Materials and methods: A prospective study was done on patients presented with suspected brain tumors based on MRI finding. After taking informed consent all patients were administered 64CuCl2(~175MBq) and brain positron emission tomography (PET)/computed tomography (CT) imaging was performed at 2 and 24 hours after administration. Standardized uptake values (SUV) were calculated. After imaging all patients advised for surgery and 64CuCl2 PET/CT imaging findings were correlated with MRI and HPE. Results: Total 15 patients have been enrolled till now. Out of 15 patients, MRI was suggestive of high-grade brain tumor in 10, low grade in 4 and meningioma in 1 patient. Eight out of 15 patients showed 64CuCl2 uptake on PET/CT with variable SUVmax (1.4- 20). HPE were suggestive of low grade astrocytoma (2 patients, SUVmax- 1.4 and 3.5 at 2 and 24 hours), pilocytic astrocytoma (2 patients, SUVmax- 3.8 and 1.5 at 2 and 24 hours), anaplastic astrocytoma (2 patient, SUVmax- 11.1 and 20.0 at 2 and 24 hours), meningothelial meningioma(SUVmax- 10.3 and 5.17 at 2 and 24 hours) and atypical meningioma (SUVmax- 2.4 and 1.3 at 2 and 24 hours). In 7 patients with no uptake on PET-CT, HPE was available in 2 patients, which revealed anaplastic oligoastrocytoma and oligodendroglioma. For rest of the 5 patient, HPE was not available. Conclusion: This preliminary study suggests that 64CuCl2 is accumulating in some but not all high-grade brain tumors. There appears to variability in the grade of Copper uptake in all grades of tumors. More data is being accumulated to define the cutoff of copper uptake as potential differentiating features for identifying possible theragnostic targets.