PT  - JOURNAL ARTICLE
AU  - Jing Ning
AU  - Peng Yu
AU  - Mu Lin
AU  - Xiang Feng
AU  - Haodan Dang
AU  - Jiajin Liu
AU  - Baixuan Xu
AU  - JiaHe Tian
TI  - Texture Analysis of <sup>11</sup>C-methinine PET Images may Facilitate to Evaluate the MGMT Methylation Status in Gliomas: Based on Integrated PET/MR Imaging
DP  - 2019 May 01
TA  - Journal of Nuclear Medicine
PG  - 396--396
VI  - 60
IP  - supplement 1
4099  - http://jnm.snmjournals.org/content/60/supplement_1/396.short
4100  - http://jnm.snmjournals.org/content/60/supplement_1/396.full
SO  - J Nucl Med2019 May 01; 60
AB  - 396Background: No published studies has analyzed textural features of 18F-FDG and11C- MET PET images using integrated PET/MR to explore the relation between comprehensive information of gliomas and MGMT promoter methylation status. Objectives: The aim of our study is to evaluate the MGMT methylation status non-invasively by analyzing textural features of multi-modality integrated PET/MR images, reaching out to the detailed biological properties of gliomas and bridge researches with clinical practice.Methods: Data was collected from 73 patients with histopathologically confirmed glioma in whom preoperative 18F-FDG PET/MR and 11C- MET PET/MR scans were performed from January 2016 to September 2018.We examined MGMT promoter methylation by pyrosequencing analysis. Results: The Skewness and Kurtosis value of the MGMT methylated group were all higher than that of the MGMT unmethylated group (0.88±0.71 vs. 0.53±0.49, respectively; P= 0.045); (1.35±2.33 vs. 0.15±0.73, respectively; P= 0.008). Conclusions: Our results add new information to the biological behaviors and imaging characteristics of gliomas according to the MGMT methylation status using MET and FDG integrated PET/MR. We have demonstrated that the MGMT methylated group showed higher glucose uptake than that in the unmethylated group, whereas MET uptake was not significantly different between the two groups. However, novelty is that the texture features Skewness and Kurtosis of MET PET images can be regarded as a key maker to evaluate the MGMT methylation status. Further studies, aiming to clarify the imaging parameters in relation to tumor biological characteristics, are desperately needed to strengthen the validity of integrated PET/MR as a noninvasive marker of MGMT methylation in a larger and prospective manner.