PT - JOURNAL ARTICLE AU - Jun Zhang AU - Maryam Lustberg AU - Katherine Binzel AU - Yu-Lung Hsieh AU - Michael Friel AU - Taylor Porter AU - Melissa Magyer AU - Richard Moore AU - Michael Knopp TI - Feasibility of Performing Clinical Low Dose and Fast Brain PET Imaging Enabled by SiPM Digital Photon Counting PET/CT DP - 2019 May 01 TA - Journal of Nuclear Medicine PG - 383--383 VI - 60 IP - supplement 1 4099 - http://jnm.snmjournals.org/content/60/supplement_1/383.short 4100 - http://jnm.snmjournals.org/content/60/supplement_1/383.full SO - J Nucl Med2019 May 01; 60 AB - 383Purpose: To evaluate the feasibility of performing low dose and fast brain FDG-PET imaging in clinical and clinical trials using SiPM digital photon counting (DPC) PET/CT. Materials and Methods: 10 oncology patients with breast cancer (BMI=33±7) were enrolled to assess neurometabolic changes and imaged before and after chemotherapy (interval=77±10 days). Low dose FDG brain PET (3.1±0.2mCi) was performed on a DPC PET/CT (Vereos, Philips) with 0.5, 1, 2 and 5 min frame durations compared to the standard of care (SOC) 10min frame duration. All data were reconstructed with 2mm isotropic voxels using TOF 3D-OSEM, and assessed with 90 brain regions using MIMSoftware and Atlas mapping. SUV & Z-Score were calculated. 3D-Hoffman phantom PET scans (0.5-10min, 0.6-2mCi FDG) were performed. Blind image reviews were performed by radiologists. Results: Compared to the 10min SOC PET, an average of 2.5±3.0%, 1.7±2.3%, 1.2±1.5% and 0.7±0.9% SUVmean difference across 90 regions of all patients were obtained for low dose PET of 0.5, 1, 2 and 5min, and no significant differences (p>0.05) in % change of therapy response were found for low dose brain PET of 1min (-7±22%), 2min (-6±22%) and 5min (-7±21%) except at 0.5 min (6±22%, p<0.01). When reducing the low dose PET below 1min acquisition times, noise appeared to be more noticeable within certain regions. We found robust Z-Scores (≤10% variances) for the 1-5min low dose PET compared to the SOC 10min’s. Hoffman phantom scans consistently revealed robust image quality and quantitative accuracy for all low dose PET ≥1min. Conclusions: The study quantitatively evaluated the feasibility of performing low dose brain FDG-PET (3mCi) with fast acquisition. Neuro brain FDG PET acquisition can be substantially accelerated using the emerging SiPM DPC PET to improve patient comfort, reduce motion artifacts and enable clinical brain trials requiring multiple time points of PET/CT scans.