PT  - JOURNAL ARTICLE
AU  - Tainturier, Laure-Eugenie
AU  - Branger, Pierre
AU  - Bouthiba, Mohammed Abdeldjalil
AU  - Nganoa, Catherine
AU  - Enilorac, Blandine
AU  - Desmonts, Cedric
AU  - Agostini, Denis
TI  - <strong>Performance evaluation of a new multipurpose whole-body Czt-based camera in brain with <sup>123</sup>I-FP-CIT : comparison with a dual head anger camera</strong>
DP  - 2019 May 01
TA  - Journal of Nuclear Medicine
PG  - 1392--1392
VI  - 60
IP  - supplement 1
4099  - http://jnm.snmjournals.org/content/60/supplement_1/1392.short
4100  - http://jnm.snmjournals.org/content/60/supplement_1/1392.full
SO  - J Nucl Med2019 May 01; 60
AB  - 1392Objectives: Based upon the breakthrough of cardiac CZT cameras, there is now an interest to apply this same technology to other SPECT imaging targets. Recently, an organ specific CZT-SPECT scanner (VERITON®Spectrum Dynamics, Caesarea, Israel) that utilizes a focused body/organ and contouring detector technology has been introduced. The aim of this study was to compare dopamine transporter SPECT imaging between a conventional and the VERITON® cameras, with different reconstruction algorithms. Methods: With the approval of the ethical committee, for patients undergoing the routine clinical procedures as part of their clinically referred care, dopamine transporter SPECT imaging have been acquired twice with a conventional gamma camera and the VERITON® camera, with no additional injection of radiopharmaceutical. 123I-FP-CIT brain SPECT data were acquired for 30 minutes on conventional dual head anger camera, reconstructed using both FPB and OSEM iterative algorithms (4, 8, 12 and 16 iterations) and filtered with a Butterworth filter. Then the data were acquired for 15 minutes (10 and 5 minutes with mode-list) in body contouring mode using 12 CZT detectors and 180 projections per detector, reconstructed using OSEM iterative algorithms (4, 8, 12 and 16 iterations) with resolution recovery, 2.46mm voxel size, 8 subsets, Chang attenuation correction (0.12) and filtered with a Gaussian filter (8 mm). Results: To date, dopamine transporter SPECT imaging have been acquired in 9 patients (age: 71±6 years, 7 males) injected with 145.6±7.7 MBq of 123I-FP-CIT. After calculating the mean striatum ratio ((StriatumROI-OccipitalROI)/OccipitalROI) for all patients , we obtained 3.42±1.31 for VERITON 15min, 3.15±0.95 for VERITON 10min, 3.40±1.26 for VERITON 5min, 2.6±1.26 for ANGER iterative OSEM and 2.12±0.71 for ANGER FBP. Friedman’s test showed significant difference between groups (p = 0.033). On pairwise comparisons using Nemenyi’s procedure, a significant difference was found only between VERITON 15min and ANGER FBP groups (p = 0.026). Conclusions: Initial experience with the CZT-SPECT system has shown that it is possible to acquire a dopamine transporter SPECT image in approximately 15 minutes, half the time required for a conventional SPECT system (~30 minutes), and with a better spatial resolution.