RT Journal Article SR Electronic T1 Feasibility of Rapid Integrated Radiation Therapy Planning with follow up FDG PET / CT to improve overall treatment assessment in Head and Neck Cancer JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 359 OP 359 VO 60 IS supplement 1 A1 Morgan, Rustain A1 Chin, Bennett A1 Lanning, Ryan YR 2019 UL http://jnm.snmjournals.org/content/60/supplement_1/359.abstract AB 359Background: Inflammatory changes and residual disease are difficult to distinguish after high dose, definitive radiotherapy of head and neck malignancies. FDG uptake located within a high dose field may more likely represent inflammatory changes, and FDG uptake outside of the radiation field could represent unsuspected and under treated disease. In situknowledge of the precise radiotherapy fields, therefore, may be useful in distinguishing these etiologies. This study evaluates the clinical feasibility of rapid integration of radiation treatment field images during follow-up FDG PET/CT imaging. Materials and Methods: Twenty head and neck cancer patients who underwent radiation therapy were identified. A MIM based workflow was created which fused the radiation treatment CT, including the planning volumes and isodose curves, into the follow-up imaging. Two board certified physicians, blinded to treatment outcome, reviewed the follow-up exams, half with the treatment information and half without. Each exam was scored for recurrent/residual disease, confidence of the read and a qualitative assessment to the overall usefulness of the treatment plan. Results: Interpretation accuracy improved from 80 to 90% with integration of the treatment plan. Similarly, the sensitivity improved from 71% to 86%, while the specificity increased from 85% to 92%. Confidence also increased by 0.7 on a 5-point scale for both readers. Conclusion: Data demonstrate the clinical feasibility of rapidly incorporating radiation treatment dosimetry into follow-up FDG PET / CT exams in patients with head and neck cancer. Preliminary results demonstrated a simple, efficient method which improved accuracy of interpretation and overall reader confidence.