TY - JOUR T1 - FDG-PET/CT imaging for assessment of maxillary sinus mucosal membrane lesions JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1199 LP - 1199 VL - 60 IS - supplement 1 AU - Abdulrahman Aseri AU - Abdullah Al-zaghal AU - Thomas Werner AU - Jonathon Korostoff AU - Høilund-carlsen Poul AU - Abass Alavi Y1 - 2019/05/01 UR - http://jnm.snmjournals.org/content/60/supplement_1/1199.abstract N2 - 1199Objectives: Maxillary sinus membrane thickening is the most commonly reported pathology in the sinuses with a higher prevalence in men. It can be influenced by several factors such as sex, age, smoking, seasons and dental infections in neighboring teeth. Different structural imaging modalities have been used to evaluate membrane thickening in the maxillary sinus like cone beam computed topography (CBCT) and magnetic resonance imaging (MRI). However, the literature is poor in reports on the use of functional imaging in this setting. The aim of this study was to investigate sinus membrane thickening (SMT) using FDG-PET/CT and to evaluate the effects of age and smoking. Methods: The CAMONA clinical trial consists of 89 healthy control subjects and 50 patients with a history of chest pain. Healthy volunteers were recruited from the general population or from the blood bank of Odense University Hospital, Denmark. PET/CT images were acquired 180-minute post intravenous administration of FDG. OsiriX® MD v.9.0 software (Pixmeo SARL, Bernex, Switzerland) was used for image analysis. All the sinuses were visually inspected to detect sinus abnormalities. A total of 34 subjects (24 healthy and 10 with history of chest pain) were presented with SMT. Three subjects were excluded due to motion artifact and one due to metallic root canal restoration close to the sinus membrane. Thus, 30 subjects were included (mean 48.6 years ±12.3, range 25 - 69, 15 males). Fifteen subjects were smokers. The volumes of the right and left maxillary sinus were calculated by measuring the area in cm2 on transverse views and then multiplying it by the slice thickness in cm (Figure1). The same method was used to calculate the lesion volumes and for characterizing cases by either having unilateral or bilateral lesion involvement. The average SUV was determined by drawing a region of interest (ROI) of 5 mm at the center of lesions (Figure2). The average SUVmean was used to semi-quantify FDG uptake in the membrane. Then global uptake was calculated based on the following equations:Global Tissue Metabolism = ROI SUV [asterisk] (SMT) Volume. For statistical analysis, student’s t-test was used to assess the difference between males and females and smokers and non-smokers), while linear regression analysis was utilized to investigate the correlation between sinus and sinus membrane volume with age. Results: In this study smokers’ average sinus membrane volume was found to be larger than that of non-smokers (mean= 3.7± 2.7 cm3 vs 1.8±1.4 cm3) with no significant difference (P=0.12). Moreover, smokers tend to have bilateral involvement of SMT (n=10, 67%), as opposed to, non-smokers where unilateral involvement was seen (n=9,60%). Global SUVmean was found to be higher in smokers when compared to non-smoker subjects (3.8±3.12 and 1.7.2±1.16, respectively) with statistically significant difference (P=0.02) (Figure 3). Male subjects presented with thicker sinus membrane when compared to female (mean= 3.7 ±2.6 cm3 vs 2.8± 2 cm3, respectively) with no significant difference (P=0.3). No correlation was found between sinus volume and SMT with age. Conclusions: Our data generated in this study suggest that FDG-PET/CT imaging is a promising approach for evaluating metabolic activity in maxillary sinus lesions. Smokers appears to have significantly higher FDG uptake in the sinus lesions and have more bilateral involvement when compared to non-smokers. Age and gender appear to have no significant effect on SMT. ER -