TY - JOUR T1 - Evaluation of effect of post infective sequelae on brain metabolism using 18F-labelled fluoro-2-deoxyglucose positron emission tomography using dedicated neurological quantification algorithms in patients with Tubercular Meningitis JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1480 LP - 1480 VL - 60 IS - supplement 1 AU - Kasturi Rangan AU - Sanjay Gambhir AU - Amrin Israrahmed AU - Kanti D AU - Mehrotra M Y1 - 2019/05/01 UR - http://jnm.snmjournals.org/content/60/supplement_1/1480.abstract N2 - 1480Background: The relevance of loss of cerebral function after post infective sequelae is not well understood in patients with tubercular meningitis. Clinical and neurophysiological studies provide adequate evidence supporting reorganization of the function centers in brain post trauma/infection. However these reorganizations are not well studied in terms of brain metabolism. Hence, we used dedicated neurological quantification algorithms to elicit the functional changes in brain after infective sequelae. Materials and Methods: 18F-FDG PET-CT scan was performed in 50 patients, of which patients with tubercular meningitis were 23 in number and rest of the 27 patients were taken as healthy subjects. Dedicated neurological quantification algorithms(MI Neuro, True Point PET-CT System, Biograph 64, Siemens, Germany) was used to evaluate the brain metabolic status in either group and comparison was done using appropriate statistical analysis using(IBM, SPSS, version 22) Results and Conclusions: Interesting facts about the utilization of the glucose by the brain were analyzed in both the groups. Increase in the brain activity is noted in the regions involving attention and initiation of the movement. Active tuberculoma shows significantly increased uptake in comparison to contralateral areas of the same patient and same area in the healthy patients(average SUVmax- 14.3, p-0.001). Hypometabolism was noted in 5 patients with vascular insults. Edema was prime cause for generalized skip regional hypometabolism. Also findings such as cerebral diascisis, leptomeningeal enhancement, basal exudates were observed. Relative improvement in the brain metabolism was observed in patients after 6 months into the antitubercular treatment. Permanent insults persisted to have hypometabolic profile in all the follow up scans. Hence it can be concluded that PET-CT scan using 18F-FDG as a tracer can be used as a surrogate marker to predict the prognostic outcome in those patients suffering from post infective sequelae using dedicated neurological quantification algorithms. ER -