PT  - JOURNAL ARTICLE
AU  - Ruonan Wang
AU  - Ping Wu
AU  - Li Li
AU  - Xianhai Xu
AU  - Yuetao Wang
AU  - Sijin Li
TI  - Evaluation of myocardial blood flow and coronary flow reserve with <sup>13</sup>N-Ammonia PET/CT in patients with different degrees of obstructive sleep apnea
DP  - 2019 May 01
TA  - Journal of Nuclear Medicine
PG  - 163--163
VI  - 60
IP  - supplement 1
4099  - http://jnm.snmjournals.org/content/60/supplement_1/163.short
4100  - http://jnm.snmjournals.org/content/60/supplement_1/163.full
SO  - J Nucl Med2019 May 01; 60
AB  - 163Objectives: Obstructive sleep apnea (OSA) is an emerging risk factor for cardiovascular disease. Microcirculatory dysfunction has been proposed as a potential mechanism in the pathogenesis of cardiovascular disease in OSA. In this study, we aimed to evaluate myocardial blood flow and coronary flow reserve with 13N-Ammonia positron emission tomography/computed tomography(PET/CT) in patients with different degrees of OSA. Methods: 38 patients with OSA who underwent stress/rest 13N-ammonia PET/CT in this study. Myocardial blood flow(MBF) and coronary flow reserve(CFR) were calculated automatically using quantitative PET/CT software.The subjects were divided into three groups depending on the apnea-hypopnea index(AHI),group1:mild OSA with 5 events/h≤AHI score<15 events/h (n=14),group2:moderate OSA with 15 events/h≤AHI score<30 events/h (n=8) and group3:severe OSA with AHI score≥30 events/h(n=15). Results: The mean age of all patients was 42.24±12.43 years,of which 13.56% were female. Different groups had similar features with regard to demographic and clinical variables.The mean rest myocardial blood flow(rMBF) were 0.97±0.33ml/g/min,0.82±0.11ml/g/min,0.94±0.22ml/g/min in mind,moderate and severe OSA groups,and there were no significant differences in rMBF among the 3 groups(P>0.05).The mean hyperemic myocardial blood flow(hMBF) were 3.20±1.01ml/g/min,2.72±0.88ml/g/min,2.56±0.64ml/g/min in mind,moderate and severe OSA groups. Although there were no significant differences in hMBF among the 3 groups(P>0.05), hMBF decreased gradually with the degree of OSA increasing.The mean CFR were 3.42±0.80,3.42±0.95,2.74±0.49,respectly,and there were significant differences in CFR among the 3 groups(P<0.05) ,and CFR was lower in severe group. Conclusions: The findings of this study indicate that CFR, an indicator of coronary microvascular function, is significantly impaired in patients with severe OSA. Coronary microvascular function, an early sign of atherosclerosis, can be evaluated noninvasively in these patients might be used as a predictor of cardiovascular risk.