RT Journal Article
SR Electronic
T1 New Developments in Dual-Labeled Molecular Imaging Agents
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 459
OP 465
DO 10.2967/jnumed.118.213488
VO 60
IS 4
A1 Servando Hernandez Vargas
A1 Sukhen C. Ghosh
A1 Ali Azhdarinia
YR 2019
UL http://jnm.snmjournals.org/content/60/4/459.abstract
AB Intraoperative detection of tumors has had a profound impact on how cancer surgery is performed and addresses critical unmet needs in surgical oncology. Tumor deposits, margins, and residual cancer can be imaged through the use of fluorescent contrast agents during surgical procedures to complement visual and tactile guidance. The combination of fluorescent and nuclear contrast into a multimodality agent builds on these capabilities by adding quantitative, noninvasive nuclear imaging capabilities to intraoperative imaging. This review focuses on new strategies for the development and evaluation of targeted dual-labeled molecular imaging agents while highlighting the successful first-in-human application of this technique.