TY - JOUR T1 - New Developments in Dual-Labeled Molecular Imaging Agents JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 459 LP - 465 DO - 10.2967/jnumed.118.213488 VL - 60 IS - 4 AU - Servando Hernandez Vargas AU - Sukhen C. Ghosh AU - Ali Azhdarinia Y1 - 2019/04/01 UR - http://jnm.snmjournals.org/content/60/4/459.abstract N2 - Intraoperative detection of tumors has had a profound impact on how cancer surgery is performed and addresses critical unmet needs in surgical oncology. Tumor deposits, margins, and residual cancer can be imaged through the use of fluorescent contrast agents during surgical procedures to complement visual and tactile guidance. The combination of fluorescent and nuclear contrast into a multimodality agent builds on these capabilities by adding quantitative, noninvasive nuclear imaging capabilities to intraoperative imaging. This review focuses on new strategies for the development and evaluation of targeted dual-labeled molecular imaging agents while highlighting the successful first-in-human application of this technique. ER -