PT - JOURNAL ARTICLE AU - Sangwon Han AU - Chong Hyun Suh AU - Sungmin Woo AU - Yeon Joo Kim AU - Jong Jin Lee TI - Performance of <sup>68</sup>Ga-DOTA–Conjugated Somatostatin Receptor–Targeting Peptide PET in Detection of Pheochromocytoma and Paraganglioma: A Systematic Review and Metaanalysis AID - 10.2967/jnumed.118.211706 DP - 2019 Mar 01 TA - Journal of Nuclear Medicine PG - 369--376 VI - 60 IP - 3 4099 - http://jnm.snmjournals.org/content/60/3/369.short 4100 - http://jnm.snmjournals.org/content/60/3/369.full SO - J Nucl Med2019 Mar 01; 60 AB - We performed a systematic review and metaanalysis of the performance of 68Ga-DOTA–conjugated somatostatin receptor–targeting peptide (68Ga-DOTA-SST) PET in the detection of pheochromocytomas and paragangliomas (PPGLs). Methods: PubMed and Embase were searched until May 8, 2018. We included studies that reported the detection rate of 68Ga-DOTA-SST PET in patients with PPGLs. Detection rates were pooled using a random-effects model. Subgroup analyses and metaregression were performed to explore the cause of heterogeneity. Results: Thirteen studies were included for qualitative synthesis. Per-lesion detection rates of 68Ga-DOTA-SST PET were consistently higher (ranging from 92% to 100%) than other imaging modalities, including 18F-fluorohydroxyphenylalanine (18F-FDOPA) PET, 18F-FDG PET, and 123/131I-metaiodobenzylguanidine (123/131I-MIBG) scintigraphy. However, in patients with polycythemia/paraganglioma syndrome, the detection rate of 68Ga-DOTA-DOTATATE PET was 35%. Nine studies (215 patients) with no specific inclusion criteria for subtype were quantitatively synthesized. The pooled detection rate was 93% (95% confidence interval [CI], 91%–95%), which was significantly higher than that of 18F-FDOPA PET (80% [95% CI, 69%–88%]), 18F-FDG PET (74% [95% CI, 46%–91%]), and 123/131I-MIBG scan (38% [95% CI, 20%–59%], P &lt; 0.001 for all). A greater prevalence of head and neck paragangliomas was associated with higher detection rates of 68Ga-DOTA-SST PET (P = 0.0002). Conclusion: 68Ga-DOTA-SST PET exhibited superior performance for lesion detection, over other functional imaging modalities, in patients with PPGLs, with the exception of polycythemia/paraganglioma syndrome. This might suggest 68Ga-DOTA-SST PET as a first-line imaging modality for the primary staging of PPGL or the restaging of PPGL with unknown genetic status.