TY - JOUR T1 - Use of <sup>18</sup>F-ASEM PET to Determine the Availability of the α7-Nicotinic Acetylcholine Receptor in Recent-Onset Psychosis JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 241 LP - 243 DO - 10.2967/jnumed.118.213686 VL - 60 IS - 2 AU - Jennifer M. Coughlin AU - Yong Du AU - Jeffrey L. Crawford AU - Leah H. Rubin AU - Babak Behnam Azad AU - Wojciech G. Lesniak AU - Andrew G. Horti AU - David J. Schretlen AU - Akira Sawa AU - Martin G. Pomper Y1 - 2019/02/01 UR - http://jnm.snmjournals.org/content/60/2/241.abstract N2 - Limited postmortem evidence suggests a diminished availability of the α7 -nicotinic acetylcholine receptor (α7-nAChR) in the hippocampus in psychosis. Methods: In this cross-sectional study, we used PET with 18F-ASEM (18F-JHU82132; 3-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-6-[18F]fluorodibenzo[b,d]thiophene 5,5-dioxide), a radiotracer targeting the α7-nAChR, to compare the binding of 18F-ASEM in the hippocampus of individuals who had recent-onset psychosis with that in healthy controls. Results: Individuals with recent-onset psychosis (nonaffective psychosis or affective psychosis), particularly those with nonaffective psychosis, showed lower hippocampal binding of 18F-ASEM than healthy controls. Among patients, lower binding was associated with lower performance in 2 cognitive domains after controlling for age. Conclusion: Low availability of the α7-nAChR in the hippocampus may be linked to recent-onset psychosis. Further study is needed to assess its clinical relationship to neuropsychiatric symptoms. ER -