RT Journal Article
SR Electronic
T1 Use of <sup>18</sup>F-ASEM PET to Determine the Availability of the α7-Nicotinic Acetylcholine Receptor in Recent-Onset Psychosis
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 241
OP 243
DO 10.2967/jnumed.118.213686
VO 60
IS 2
A1 Coughlin, Jennifer M.
A1 Du, Yong
A1 Crawford, Jeffrey L.
A1 Rubin, Leah H.
A1 Azad, Babak Behnam
A1 Lesniak, Wojciech G.
A1 Horti, Andrew G.
A1 Schretlen, David J.
A1 Sawa, Akira
A1 Pomper, Martin G.
YR 2019
UL http://jnm.snmjournals.org/content/60/2/241.abstract
AB Limited postmortem evidence suggests a diminished availability of the α7 -nicotinic acetylcholine receptor (α7-nAChR) in the hippocampus in psychosis. Methods: In this cross-sectional study, we used PET with 18F-ASEM (18F-JHU82132; 3-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-6-[18F]fluorodibenzo[b,d]thiophene 5,5-dioxide), a radiotracer targeting the α7-nAChR, to compare the binding of 18F-ASEM in the hippocampus of individuals who had recent-onset psychosis with that in healthy controls. Results: Individuals with recent-onset psychosis (nonaffective psychosis or affective psychosis), particularly those with nonaffective psychosis, showed lower hippocampal binding of 18F-ASEM than healthy controls. Among patients, lower binding was associated with lower performance in 2 cognitive domains after controlling for age. Conclusion: Low availability of the α7-nAChR in the hippocampus may be linked to recent-onset psychosis. Further study is needed to assess its clinical relationship to neuropsychiatric symptoms.