RT Journal Article SR Electronic T1 68Ga-PSMA-11 PET/CT in Primary and Recurrent Prostate Carcinoma: Implications for Radiotherapeutic Management in 121 Patients JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 234 OP 240 DO 10.2967/jnumed.118.211086 VO 60 IS 2 A1 Stefan A. Koerber A1 Leon Will A1 Clemens Kratochwil A1 Matthias F. Haefner A1 Hendrik Rathke A1 Christophe Kremer A1 Jonas Merkle A1 Klaus Herfarth A1 Klaus Kopka A1 Peter L. Choyke A1 Tim Holland-Letz A1 Uwe Haberkorn A1 Juergen Debus A1 Frederik L. Giesel YR 2019 UL http://jnm.snmjournals.org/content/60/2/234.abstract AB The present study analyzed the impact of 68Ga-labeled prostate-specific membrane antigen-HBED-CC (68Ga-PSMA-11) PET/CT on radiotherapeutic management in a large cohort of men with primary or recurrent prostate cancer. Methods: This study investigated 121 men with carcinoma of the prostate who underwent 68Ga-PSMA-11 PET/CT as well as conventional imaging. Fifty patients were treatment-naive, 11 had persistent prostate-specific antigen (PSA) soon after surgery, and 60 presented with recurrent PSA after definitive therapy. Changes in TNM classification of malignant tumor stage (TNM) and radiotherapeutic management after 68Ga-PSMA-11 imaging were compared with results achieved with conventional imaging. Results: In total, a change in TNM stage and radiotherapeutic management was observed for 49 patients (40.5%) and 62 patients (51.2%), respectively. In treatment-naive patients, a change in TNM stage and radiotherapeutic plan occurred in 26.0% and 44.0% of the cohort, respectively. For patients with PSA persistence or recurrence, TNM and radiotherapeutic management changed in 50.7% and 56.3%, respectively. Conclusion: 68Ga-PSMA-11 PET/CT may shortly become an indispensable tool for detecting prostate cancer lesions in treatment-naive patients as well as in men with recurrent disease or persistent PSA and seems to be helpful in personalizing radiotherapeutic management to the individual patients’ distribution of disease.