TY - JOUR T1 - Feasibility of CXCR4-Directed Radioligand Therapy in Advanced Diffuse Large B-Cell Lymphoma JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 60 LP - 64 DO - 10.2967/jnumed.118.210997 VL - 60 IS - 1 AU - Constantin Lapa AU - Heribert Hänscheid AU - Malte Kircher AU - Andreas Schirbel AU - Gerd Wunderlich AU - Rudolf A. Werner AU - Samuel Samnick AU - Jörg Kotzerke AU - Hermann Einsele AU - Andreas K. Buck AU - Hans-Jürgen Wester AU - Götz Ulrich Grigoleit Y1 - 2019/01/01 UR - http://jnm.snmjournals.org/content/60/1/60.abstract N2 - We have recently reported on our experience with C-X-C-motif chemokine receptor 4 (CXCR4)–directed radioligand therapy (RLT) in multiple myeloma and acute leukemia. Methods: Six patients with heavily pretreated relapsed diffuse large B-cell lymphoma (3 men, 3 women; aged, 54 ± 8 y) underwent CXCR4-directed RLT in combination with conditioning chemotherapy and allogeneic stem cell transplantation. In 2 patients, radioimmunotherapy targeting CD20 or CD66 was added to enhance antilymphoma activity. Endpoints were incidence and severity of adverse events, progression-free survival, and overall survival. Results: RLT and additional radioimmunotherapy were well tolerated, without any acute adverse events or changes in vital signs. Successful engraftment was recorded after a median of 11 d (range, 9–13 d). Of the 4 patients who were available for follow-up (one patient died of CNS aspergillosis 29 d after RLT and another of sepsis in aplasia 34 d after RLT), CXCR4-directed RLT resulted in a partial response in two (both treated with additional radioimmunotherapy) and a mixed response in the remaining two. The response duration was rather short-lived, with a median progression-free survival of 62 d (range, 29–110 d) and a median overall survival of 76 d (range, 29–334 d). Conclusion: CXCR4-directed RLT (in combination with additional radioimmunotherapy) is feasible as a conditioning regimen before allogeneic stem cell transplantation in diffuse large B-cell lymphoma. ER -