PT  - JOURNAL ARTICLE
AU  - Rajiv Radhakrishnan
AU  - Nabeel Nabulsi
AU  - Edward Gaiser
AU  - Jean-Dominique Gallezot
AU  - Shannan Henry
AU  - Beata Planeta
AU  - Shu-fei Lin
AU  - Jim Ropchan
AU  - Wendol Williams
AU  - Evan Morris
AU  - Deepak Cyril D’Souza
AU  - Yiyun Huang
AU  - Richard E. Carson
AU  - David Matuskey
TI  - Age-Related Change in 5-HT<sub>6</sub> Receptor Availability in Healthy Male Volunteers Measured with <sup>11</sup>C-GSK215083 PET
AID  - 10.2967/jnumed.117.206516
DP  - 2018 Sep 01
TA  - Journal of Nuclear Medicine
PG  - 1445--1450
VI  - 59
IP  - 9
4099  - http://jnm.snmjournals.org/content/59/9/1445.short
4100  - http://jnm.snmjournals.org/content/59/9/1445.full
SO  - J Nucl Med2018 Sep 01; 59
AB  - Serotonin receptor 6 (5-hydroxytrypamine-6, or 5-HT6) is a potential therapeutic target given its distribution in brain regions that are important in depression, anxiety, and cognition. This study sought to investigate the effects of age on 5-HT6 receptor availability using 11C-GSK215083, a PET ligand with affinity for 5-HT6 in the striatum and 5-HT2A in the cortex. Methods: Twenty-eight healthy male volunteers (age range, 23–52 y) were scanned with 11C-GSK215083 PET. Time–activity curves in regions of interest were fitted using a multilinear analysis method. Nondisplaceable binding potential (BPND) was calculated using the cerebellum as the reference region and corrected for partial-volume effects. Results: In 5-HT6–rich areas, regional 11C-GSK215083 showed a negative correlation between BPND and age in the caudate (r = −0.41, P = 0.03) (14% change per decade) and putamen (r = −0.30, P = 0.04) (11% change per decade) but not in the ventral striatum or pallidum. A negative correlation with age was also seen in cortical regions (r = −0.41, P = 0.03) (7% change per decade), consistent with the literature on 5-HT2A availability. Conclusion: To our knowledge, this was the first in vivo study on humans to examine the effect of age on 5-HT6 receptor availability. The study demonstrated a significant age-related decline in 5-HT6 availability (BPND) in the caudate and putamen.