RT Journal Article
SR Electronic
T1 Insights into Trace Metal Metabolism in Health and Disease from PET: “PET Metallomics”
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1355
OP 1359
DO 10.2967/jnumed.118.212803
VO 59
IS 9
A1 Bartnicka, Joanna J.
A1 Blower, Philip J.
YR 2018
UL http://jnm.snmjournals.org/content/59/9/1355.abstract
AB Essential trace metals such as copper, zinc, iron, and manganese perform critical functions in cellular and physiologic processes including catalytic, regulatory, and signaling roles. Disturbed metal homeostasis is associated with the pathogenesis of diseases such as dementia, cancer, and inherited metabolic abnormalities. Intracellular pathways involving essential metals have been extensively studied but whole-body fluxes and transport between different compartments remain poorly understood. The growing availability of PET scanners and positron-emitting isotopes of key essential metals, particularly 64Cu, 63Zn, and 52Mn, provide new tools with which to study these processes in vivo. This review highlights opportunities that now present themselves, exemplified by studies of copper metabolism that are in the vanguard of a new research front in molecular imaging: “PET metallomics.”