PT  - JOURNAL ARTICLE
AU  - Leite, Jose
AU  - Moreira, Renata
AU  - Zema, Tassia
AU  - Moreira, Mayra
TI  - Acute leukemia: The wide spectrum of imaging findings on an FDG PET-CT study.
DP  - 2018 May 01
TA  - Journal of Nuclear Medicine
PG  - 1167--1167
VI  - 59
IP  - supplement 1
4099  - http://jnm.snmjournals.org/content/59/supplement_1/1167.short
4100  - http://jnm.snmjournals.org/content/59/supplement_1/1167.full
SO  - J Nucl Med2018 May 01; 59
AB  - 1167Purpose: TEACHING POINTS 1) Despite acute leukemia not being considered a formal indication for a FDG-PET/CT study, it is important to recognize its findings, since sings/symptoms underlying this disease are well-established FDG-PET/CT indications, such as fever of unknown origin, persistent hematologic disturb, weight loss, among others. 2) There is a wide spectrum of imaging findings on the FDG-PET/CT study, from a faint to very intense diffuse FDG uptake in bone marrow, to the presence of extramedullary/visceral lesions, such as spleen, liver, testicle, ovaries, uterus etc. 3) As a non-specific finding, diffuse FDG bone marrow uptake identified in a PET/CT examination, can make sometimes the study interpretation challenging. So it is important to discuss others differential diagnoses of this entity. TABLE OF CONTENTS/OUTLINE 1) To discuss the pathophysiology of acute leukemia and its clinical and laboratorial presentation. 2) Review the spectrum of acute leukemia FDG-PET/CT findings through a series of cases and its correlation to the clinical and hematological data.3) How to optimize the interpretation of this non-specific finding (FDG diffuse bone marrow uptake) in correlation to clinical history, laboratorial findings, and other illness that can present this entity (specially lymphomas, benign hematologic disease and inflammatory/infectious disorders).