RT Journal Article SR Electronic T1 Positron Emission Mammography in management of new diagnosed breast cancer routine management JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 415 OP 415 VO 59 IS supplement 1 A1 Levent Guner A1 Kemal Unal A1 Burcin Tutar A1 Halil Kara A1 Gul Esen Icten A1 Cihan Uras A1 Erkan Vardareli YR 2018 UL http://jnm.snmjournals.org/content/59/supplement_1/415.abstract AB 415Aim: Positron emission mammography (PEM) is a localized imaging modality with superior spatial resolution compared to whole body PET (WB PET). We evaluated PEM's contribution to routine practice of breast cancer staging to WB PET. Methods: We evaluated 25 patients referred to our department for breast cancer staging between 1.9.2017 and 31.12.2017. All the patients had routine whole body PET-CT scans followed by PEM scans of the breast that the lesion was located in. Of the 25, 12/25 (48%) patients had PET findings consistent with locally advanced disease (10/25) or distant metastasis (2/25). 13/25 (52%) patients had local disease that was followed by surgery. Mean age was 50.6+-12.3. WB PET and PEM primary tumor SUV's were highly correlated (corr coeff 0.95). PEM SUV was correlated with both Ki-67 and histological grade (corr coeff 0.57 and 0.63 respectively). 3/25 (12%) patients had triple negative tumors (WB PET SUV's 5.9, 2.9 and 29), four patients had HER2 enriched disease (6.17, 14.41, 7.26 and 17.72), other luminal subtypes had average WB PET SUV 7.8+-5.6. Pathology reported size of the lesions in patients who had surgery were 22.1+-9.3mm's. Mean of the SUV's of breast lesions in WB PET was 8.9+-6.7, while of PEM was 20.6+-13.7. Additional lesion(s) were detected in PEM compared to WBPET in 5/25 (20%) patients. On the other hand, in four patients primary lesion was not detected in PEM, of these one of them was also not seen in WB PET. Other three (12%) were outside PEM field of view. Lesion not detected in both WB PET and PEM had grade 1 tumor, Ki-67 of 5% and 7mm's diameter. None of the patients who had surgery after PEM (n=13) had additional lesions not reported in conventional breast imaging. One patient with two additional lesions in each breast had sclerosing adenosis. Conclusions: WB PET SUV's and PEM SUV's were highly correlated, and both were correlated to Ki-67 and histological grade. Additional lesions were detected in PEM scans in a significant number of patients compared to WB PET, while another significant proportion of patients had lesions not visualized only in PEM due to positioning.