RT Journal Article
SR Electronic
T1 Recent Development of Technology and Application of Photoacoustic Molecular Imaging Toward Clinical Translation
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1202
OP 1207
DO 10.2967/jnumed.117.201459
VO 59
IS 8
A1 Jaesok Yu
A1 Ho Nhu Y. Nguyen
A1 Wiendelt Steenbergen
A1 Kang Kim
YR 2018
UL http://jnm.snmjournals.org/content/59/8/1202.abstract
AB The deep imaging capability and optical absorption contrast offered by photoacoustic imaging promote the use of this technology in clinical applications. By exploiting the optical absorption properties of endogenous chromophores such as hemoglobin and lipid, molecular information at a depth of a few centimeters can be unveiled. This information shows promise to reveal lesions indicating early stage of various human diseases, such as cancer and atherosclerosis. In addition, the use of exogenous contrast agents can further extend the capability of photoacoustic imaging in clinical diagnosis and treatment. In this review, the current state of the art and applications of photoacoustic molecular probes will be critically reviewed, as well as some spearheading translational efforts that have taken place over the past 5 years. Some of the most critical barriers to clinical translation of this novel technology will be discussed, and some thoughts will be given on future endeavors and pathways.