RT Journal Article
SR Electronic
T1 <strong>Suppression of Myocardial </strong><strong><sup>18</sup></strong><strong>F-fluorodeoxyglucose </strong><strong>Uptake in Rat Model of Myocardial Ischemia with Verapamil and Heparin</strong>
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1514
OP 1514
VO 59
IS supplement 1
A1 Bi-Xi Chen
A1 Xiao-Ying Xi
A1 Jiao-Yan Wu
A1 BoQia Xie
A1 Li Wang
A1 Min-Fu Yang
YR 2018
UL http://jnm.snmjournals.org/content/59/supplement_1/1514.abstract
AB 1514Objectives: Positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) has been employed to diagnose myocardial ischemia, but requires an approach for suppression of cardiomyocyte uptake. We tested the utility of verapamil and heparin in suppressing myocardial uptake in a rat model. Methods Thirty-one male Wistar rats were divided into four groups randomly: sham, ischemia only, ischemia plus verapamil and ischemia plus heparin. Myocardial ischemia was induced by ligation of left anterior descending for 25min. Verapamil was injected 1 h prior to FDG administration at a dose of 1 mg/kg, and heparin was injected 15min prior to FDG administration at a dose of 5 U/kg. PET/CT scans were performed 60 min after injection of 18F-FDG. Results In non-ischemia zone, neither verapamil nor heparin induced significant reduction of FDG uptake (SUVmax 0.82±0.19 and 0.91±0.31; p=NS). Contrarily, both verapamil and heparin significantly suppressed myocardial FDG uptakein ischemia zone (ischemia only, 1.01±0.25; ischemia plus verapamil, 0.97±0.12; ischemia plus heparin 0.91±0.12 vs; all p&lt;0.05). Conclusion In rat model of myocardial ischemia, verapamil and heparin have similar effect on myocardial FDG uptake, only in ischemic area but not non-ischemic zone. Research Support.:The project supported by National Natural Science Foundation of China (81471694).