RT Journal Article
SR Electronic
T1 Gender differences in brown adipose tissue related brain functional networks: a PET study
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1704
OP 1704
VO 59
IS supplement 1
A1 Xiaonan Shao
A1 Yuetao Wang
YR 2018
UL http://jnm.snmjournals.org/content/59/supplement_1/1704.abstract
AB 1704Objectives: Thermogenesis of brown adipose tissue (BAT) is controlled by central modulating mechanisms, although changes in brain metabolism of BAT-positive subjects with different genders are still unclear. We hypothesized that changes in regional cerebral glucose metabolic activity were associated with BAT activities, and this association differed in different genders. Methods: Brain glucose metabolism of 26 BAT-positive and 26 BAT-negative healthy subjects was compared using a brain FDG-PET scan and gender differences in BAT-related brain functional networks were assessed by comparing the brain PET images of BAT-positive and BAT-negative subjects of different genders. Results: Compared with controls, BAT-positive males had a significant hypermetabolic area in the right extra-nuclear and significant hypometabolic areas in the right inferior parietal lobule and right inferior frontal gyrus (P<0.001) (Figure 1); while at the same threshold (k=30 pixels), BAT-positive females had richer hypermetabolic areas, including bilateral limbic lobes, bilateral frontal lobes, right cerebellum, left sub-lobar and right parietal lobes (P<0.001) (Figure 2). Conclusions: BAT-related brain functional networks are different between males and females. Female networks are greater and more concentrated while male networks are smaller and more dispersed.