PT  - JOURNAL ARTICLE
AU  - Xiaonan Shao
AU  - Yuetao Wang
TI  - Gender differences in brown adipose tissue related brain functional networks: a PET study
DP  - 2018 May 01
TA  - Journal of Nuclear Medicine
PG  - 1704--1704
VI  - 59
IP  - supplement 1
4099  - http://jnm.snmjournals.org/content/59/supplement_1/1704.short
4100  - http://jnm.snmjournals.org/content/59/supplement_1/1704.full
SO  - J Nucl Med2018 May 01; 59
AB  - 1704Objectives: Thermogenesis of brown adipose tissue (BAT) is controlled by central modulating mechanisms, although changes in brain metabolism of BAT-positive subjects with different genders are still unclear. We hypothesized that changes in regional cerebral glucose metabolic activity were associated with BAT activities, and this association differed in different genders. Methods: Brain glucose metabolism of 26 BAT-positive and 26 BAT-negative healthy subjects was compared using a brain FDG-PET scan and gender differences in BAT-related brain functional networks were assessed by comparing the brain PET images of BAT-positive and BAT-negative subjects of different genders. Results: Compared with controls, BAT-positive males had a significant hypermetabolic area in the right extra-nuclear and significant hypometabolic areas in the right inferior parietal lobule and right inferior frontal gyrus (P<0.001) (Figure 1); while at the same threshold (k=30 pixels), BAT-positive females had richer hypermetabolic areas, including bilateral limbic lobes, bilateral frontal lobes, right cerebellum, left sub-lobar and right parietal lobes (P<0.001) (Figure 2). Conclusions: BAT-related brain functional networks are different between males and females. Female networks are greater and more concentrated while male networks are smaller and more dispersed.