TY - JOUR T1 - α-Emitters for Radiotherapy: From Basic Radiochemistry to Clinical Studies—Part 2 JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1020 LP - 1027 DO - 10.2967/jnumed.117.204651 VL - 59 IS - 7 AU - Sophie Poty AU - Lynn C. Francesconi AU - Michael R. McDevitt AU - Michael J. Morris AU - Jason S. Lewis Y1 - 2018/07/01 UR - http://jnm.snmjournals.org/content/59/7/1020.abstract N2 - The use of radioactive sources to deliver cytotoxic ionizing radiation to disease sites dates back to the early 20th century, with the discovery of radium and its physiologic effects. α-emitters are of particular interest in the field of clinical oncology for radiotherapy applications. The first part of this review explored the basic radiochemistry, high cell-killing potency, and availability of α-emitting radionuclides, together with hurdles such as radiolabeling methods and daughter redistribution. The second part of this review will give an overview of the most promising and current uses of α-emitters in preclinical and clinical studies. ER -