PT  - JOURNAL ARTICLE
AU  - Sophie Poty
AU  - Lynn C. Francesconi
AU  - Michael R. McDevitt
AU  - Michael J. Morris
AU  - Jason S. Lewis
TI  - α-Emitters for Radiotherapy: From Basic Radiochemistry to Clinical Studies—Part 2
AID  - 10.2967/jnumed.117.204651
DP  - 2018 Jul 01
TA  - Journal of Nuclear Medicine
PG  - 1020--1027
VI  - 59
IP  - 7
4099  - http://jnm.snmjournals.org/content/59/7/1020.short
4100  - http://jnm.snmjournals.org/content/59/7/1020.full
SO  - J Nucl Med2018 Jul 01; 59
AB  - The use of radioactive sources to deliver cytotoxic ionizing radiation to disease sites dates back to the early 20th century, with the discovery of radium and its physiologic effects. α-emitters are of particular interest in the field of clinical oncology for radiotherapy applications. The first part of this review explored the basic radiochemistry, high cell-killing potency, and availability of α-emitting radionuclides, together with hurdles such as radiolabeling methods and daughter redistribution. The second part of this review will give an overview of the most promising and current uses of α-emitters in preclinical and clinical studies.