PT  - JOURNAL ARTICLE
AU  - Denise S. O’Keefe
AU  - Dean J. Bacich
AU  - Steve S. Huang
AU  - Warren D.W. Heston
TI  - A Perspective on the Evolving Story of PSMA Biology, PSMA-Based Imaging, and Endoradiotherapeutic Strategies
AID  - 10.2967/jnumed.117.203877
DP  - 2018 Jul 01
TA  - Journal of Nuclear Medicine
PG  - 1007--1013
VI  - 59
IP  - 7
4099  - http://jnm.snmjournals.org/content/59/7/1007.short
4100  - http://jnm.snmjournals.org/content/59/7/1007.full
SO  - J Nucl Med2018 Jul 01; 59
AB  - In this review, we cover the evolution of knowledge on the biology of prostate-specific membrane antigen (PSMA) and its translation to therapy. The usual key to discovery is a realistic model for experimentation and for testing a hypothesis. A realistic model is especially needed in the case of the human prostate, which differs significantly from the prostate of species often used as research models. We will emphasize the genetic characterization of PSMA, the nature of the PSMA protein, and its role as a carboxypeptidase, with differing important substrates and products in different tissues. We give special prominence to the importance of PSMA as a target for imaging and therapy in prostate cancer and its underdeveloped role for imaging and targeting the neovasculature of tumors other than prostate cancer. Lastly, we bring attention to its importance in other nonprostatic tissues.