RT Journal Article
SR Electronic
T1 Same-Day Imaging Using Small Proteins: Clinical Experience and Translational Prospects in Oncology
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 885
OP 891
DO 10.2967/jnumed.117.199901
VO 59
IS 6
A1 Krasniqi, Ahmet
A1 D’Huyvetter, Matthias
A1 Devoogdt, Nick
A1 Frejd, Fredrik Y.
A1 Sörensen, Jens
A1 Orlova, Anna
A1 Keyaerts, Marleen
A1 Tolmachev, Vladimir
YR 2018
UL http://jnm.snmjournals.org/content/59/6/885.abstract
AB Imaging of expression of therapeutic targets may enable stratification of patients for targeted treatments. The use of small radiolabeled probes based on the heavy-chain variable region of heavy-chain–only immunoglobulins or nonimmunoglobulin scaffolds permits rapid localization of radiotracers in tumors and rapid clearance from normal tissues. This makes high-contrast imaging possible on the day of injection. This mini review focuses on small proteins for radionuclide-based imaging that would allow same-day imaging, with the emphasis on clinical applications and promising preclinical developments within the field of oncology.