RT Journal Article
SR Electronic
T1 α-Emitters for Radiotherapy: From Basic Radiochemistry to Clinical Studies—Part 1
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 878
OP 884
DO 10.2967/jnumed.116.186338
VO 59
IS 6
A1 Sophie Poty
A1 Lynn C. Francesconi
A1 Michael R. McDevitt
A1 Michael J. Morris
A1 Jason S. Lewis
YR 2018
UL http://jnm.snmjournals.org/content/59/6/878.abstract
AB With a short particle range and high linear energy transfer, α-emitting radionuclides demonstrate high cell-killing efficiencies. Even with the existence of numerous radionuclides that decay by α-particle emission, only a few of these can reasonably be exploited for therapeutic purposes. Factors including radioisotope availability and physical characteristics (e.g., half-life) can limit their widespread dissemination. The first part of this review will explore the diversity, basic radiochemistry, restrictions, and hurdles of α-emitters.